Pregnancy-Associated Breast Cancer: Tumor Features and Obstetrical Outcomes in a Single Institution Retrospective Study

Results: Median maternal age at diagnosis was 33.64 years. 1 patient was classified as having clinical stage I disease, 10 as stage II, 1 as stage III, 2 as stage IV. Pregnancy was discontinued in 2 patients, for patients’ choice. Treatment was started during pregnancy in all cases. 5 women underwent surgery during pregnancy, 2 in the first trimester, 2 in the second trimester and 1 in the third trimester. Six women received chemotherapy during pregnancy. The median gestational age at chemotherapy start was 23.33 + 6.52 sd weeks. The median gestational age at delivery was 35.2 + 8.67 weeks. In 2 cases premature delivery followed spontaneous preterm labour; in 6 cases early delivery was planned to optimize treatment. Median weight was 2381.67 ± 632.60 sd kg. APGAR Score was 7.56 ± 2.60 sd at 1 minute and 8.33 ± 1.31 sd at 5 minutes. Among the six foetuses exposed to chemotherapy in utero, no miscarriages or foetal malformations were reported. At a median follow-up of 88,21 + 67,06 sd months, 10 patients were alive and free of disease, 1 was alive with disease, and 3 patients had died because of breast cancer.